Great information given by you and your staff. I know sometimes patients have been put on a higher dosage of propecia after years of being on the medication due to loss of effectiveness. If you were to go from a quarter pill to half a pill would it be better to take two quaters at different times throughout the day due to propecia’s short half life.
First of all, I’m assuming when you say you take a quarter pill, you’re talking about the 5mg Proscar… not a quarter of the 1mg Propecia.
Secondly, you must understand Propecia doesn’t actually lose effectiveness over the years, but rather you’re losing the battle as your genetic predisposition is showing through. It’s the classic game of tug-of-war. You cannot cheat genes. Now there are a few patients who do elect to take an increased dose of finasteride, but I often find that this is hit and miss as for additional benefits.
As for your question on dividing the dose to twice a day, I would think it would make better scientific sense to take it all at once, especially since you would want (in theory) a higher concentration in your body. If you break it down to twice a day, you will lose the advantage of the higher potency (all assuming this is going to work). If you take it in the morning, your testosterone level is highest, so it just might be more effective.