We are moving in the general direction of prolonging life. Drugs to slow down aging are coming and some are even here now. The basic problem with extending life may reflect the quality of the life that is extended. If we add 10 years to a person’s life, will it be worthwhile? Will we just be filling the nursing homes with more debilitated, mentally impaired people?

In the recent issue of New Scientist (October 4, 2014 called Elixer of youth? It’s already here) and good overview of what is going on in the field of the ‘Elixer of Youth’ is examined. Google believes in this future and has invested in a company called Calico, an R&D firm targeting the life span issue. Even drug companies like Novartis have now entered the field with research of “geroprotetors” (longevity drugs). Many doctors who are in the anti-aging field are taking the drugs themselves even through they are deemed experimental at this time.

Adding up to 10 years on to your life may not be so distant into the future as you might think. Drugs such as a baby aspirin daily and a statin, is believed to reduce your risk of stroke, heart disease and even dementia. The evidence is clear on the use of baby aspirin but controversial for the value of statins. Some of the most promising drugs for future use were developedin organ transplants to reduce organ rejection such as the compound rapamycin. This drug has been found to extend life in yeast, worms and mice. A drug called everolimus can reverse the deterioration of the immune system that occurs with age. “Immune system aging is a major cause of disease and death.” These drugs seem to have the same effects on humans as seen in mice but the clinical evidence is wanting. The common drug metformin, used to treat diabetes, seems to have anti-aging effects when used on non-diabetes, but has side effects in producing diabetes in people taking it. Early evidence suggest that 15% of non-diabetics taking metforman were less likely to die than other not on the drug.

In other publications, Scientists have shown a link between long-living calorie-restricted mice and the types of microbes residing in the guts of those mice. The finding, published last month (July 16, 2013) in Nature Communications, suggests a novel mechanism of living longer by establishing the right kind of microbes in our gut through a low-calorie diet. We are learning more and more that we house colonies of gut bacteria that impact us in ways we never imagined.

“[The study] underlined the effectiveness of the healthy modulation of the gut microbiota along with diet specificities,” Jean-Paul Vernoux, a professor of food toxicology at the University of Caen in France who was not involved with the study, said in an email to The Scientist.

Caloric restriction has been known to extend life span in a variety of organisms, including humans, though the molecular mechanisms of this effect are not known. Recent research has begun to outline the role of the apparently innocuous microbes of the gut in modulating metabolism and immunity of their host. Based on these findings, Liping Zhao of Shanghai Jiao Tong University and his colleagues wondered if caloric restriction may prolong life span by modulating the type and composition of gut microbes.[/bq]

Read the rest — Eat Less and Live Longer?

Mice on a low-cal diet live longer. How does that translate to humans? We’ll see.

I started to lose your hair this July. About that time I also went on hormones, DHEA, and antibiotics. Could these medications have caused my hair loss. I recently stopped taking these medications and think that the loss may have slowed and some reversal may be going on. Is this possible

I believe that considering the short period of use and the known relationships between DHEA and hair loss, it is reasonable to expect that the hair loss you had might be related to the medication. You think that the hair loss is reversing upon stopping the medication so it is reasonable to expect that your progress will continue. You need to determine the status of your hair in and around your head, get the hair and scalp mapped out for miniaturization and hair bulk with the HAIRCHECK instrument. From changes in hair thickness (in bulk) you will know where you are going with your hair loss and if it has stabilized. Good hair transplant doctors’ offices will do these test for you.

I am a medical student and was wondering how finasteride works to give people a fuller appearance of hair.

In the Journal of the American Academy of Dermatology July 2006, Volume 55, Dr. Vera Price summarized the action of finasteride as follows:

“Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men.”

This is important, because what she implies is that the miniaturized hairs reverse. That is why it is so important to map out the scalp for miniaturization and to perform bulk measurements with the HAIRCHECK instrument. These two approaches used prior to starting finasteride (Propecia) gives us a baseline metric to determine the value of the treatment. I have seen people with miniaturization in the 80% range, reduce substantially to almost normal levels (under 20%). This is why everyone taking finasteride should be evaluated prior to starting the treatment by a doctor who understands this process clearly.

Too many finasteride (Propecia) users do not get evaluated prior to starting the treatment. They depend upon their memory of what they looked like after being on the drug, the appearance of hairs falling out and found in the drain, and even photography. Considering the investment of emotion (and money) in treating hair loss, every person should be a HAIRCHECK done for bulk measurement. After a year on the drug, you will know if you are gaining, losing or just staying put. This is the critical first phase of a Master Plan for hair loss that everyone using it should undertake. These measurements along with the first visit check-up, is free at the New Hair Institute. For women, the HAIRCHECK measurement is also important for knowing where the hair loss is going.

I hear every conceivable answer to the question of washing ones hair. Should it be done daily, twice a day or weekly?

A famous hair researcher recently suggested that a wool sweater of the highest grade, if washed everyday for a year, would eventually show significant wear and tear after a year. That is because the soaps and detergents used would break apart the wool fibers with time. Better wools stand up to the detergent attacks better. So it is with hair, more washing eventually damage the hair over time as the wax that protects the hair shafts (sebum) is washed out. The shorter the hair, the less the problem as the older hair (ends of the hair) show the damage of washing over time much more than short hair. Women with long hair complain of ‘split ends’ often and this is the result of accumulated washing and drying of the hair. Blow dryers produces more damage to the hair.

For most men who do not let their hair grow to shoulder length, wash as often as you wish. Use good quality shampoos and if you add a conditioner, it will re-hydrate the hair shafts after the detergents take out the wax that normally protects the hair.

Dr Rassman,

My question is: does finasteride play any role in maintaining minoxidil dose-dependent hair?

I got started on 5% minoxidil topical in early Feb, 2009. My derm prescribed Finasteride oral 1mg/day too, but I did not pursue that medication due to the usual side-effects related concerns. There was an initial minox-induced shed: not a massive one, but scalp showed. Things started looking up 4 months later but then again in July/August a bout of minor shedding ensued. Survived that too. In November yet another shed started and this one was bad; short fine hairs all over the pillow in the morning. Scalp showed yet again, as bad as after the first shed in March. In December, I panicked, decided that Minox wasn’t working for me, and got started on Finstaride 1mg.

By mid-Feb this year, there was a sort of minor miracle on the top of my head. My hair is looking its best in maybe two years. I hope you agree with me that it’s unlikely that Finasteride started growing hair within 10 weeks of beginning its use. My (semi-literate) guess is that Minox first grew “peach fuzz”, which gave way to intermediate hair, which then was replaced by terminal hair. I suffered synchronized sheds, the last one being the shedding of intermediate hair. Maybe more sheddings are in store for me, maybe not.

To get to the point, I am so pleased with the result that I’ve gotten greedy: I want Finasteride growth too. No sexual side-effects so far. I’d like to press on with Fin, and reserve the option of discontinuing it in future if side-effects show up. I understand that that would result in catch-up loss, but then probably I’d be content with the hair that Minox grew for me.

Hence the question: do minox and Fin have a cumulative beneficial effect on the same hair follicle? Will minox-dependent hair too be lost in catch-up loss if Fin is stopped? If the answer is in the affirmative, I’d probably be better off stopping Fin right away, since I’ve been using it only for 3 months.

Thank you for a patient reading, and thank you for your time.

You would have to poll each hair follicle and ask them what they liked better. If you can not communicate with them, then you are like me who frankly does not know the answer to your question. My best guess though (keep in mind I could be mistaken) is that because the medications work in different ways and finasteride will not keep hair grown from minoxidil and vice versa, that the benefits are independent of each other. Many men do use both medications concurrently, and as long as you can afford both (and maintain the regimen) I say go for it! It’s ok to be greedy and want your hair to look as great as possible. If the meds work well for you, that’s great news!

While it is unlikely that any major hair growth you’ve seen in just 10 weeks occurred from finasteride, you could’ve seen benefits from the medication that have helped your hair look better overall. The two drugs work differently. Minoxidil will grow new hair but the quality of the new hair varies in individuals from thin and poor, to strong and good (less than 15% of people). Finasteride probably does not grow new hair, but most likely works on the miniaturized hairs that we see in male pattern balding as it progresses. This is why finasteride (Propecia) will have no effect on the new minoxidil produced hairs. Minoxidil has not been shown to work on miniaturized hairs, at least that is what is presently understood.

Dr. Rassman:

Prior to reading this, thank you for your time. Your insight and knowledge is of great appreciation.

My situation is as follows:

I started propecia, was on it for a month, then underwent a HT of 1,900 grafts mainly in the front hairline. I continued to use propecia for 2 more months and began to experience some serious sexual side effects. I stuck it out for another 3 weeks however the side effects continued so I stopped the propecia. The sad part is that the propecia began to halt my hairloss however I could not deal with the sexual side effects.

Sadly my hair is shedding. After another apt with my hair restoration doctor, he suggested I take Avodart 0.5mg twice/week. He had mentioned that some of his patients who were having side effects from Propecia took the Avodart bi-weekly, (due to the drugs long half life) and were able to halt hairloss but did not experience the side effects which I was experiencing from my daily 1mg Propecia regiment. I have read all of your posts in regards to Avodart and I understand that it is not FDA approved nor do you prescribe it to your patients.

My main question to you and issue at hand:

I know that when people start taking Avodart they experience a shedding phase which generally kicks in after the first month or two of starting the drug and can last a few months there after. My first question – If I am only taking the drug twice a week and have only been off of propecia for 4 weeks will I also experience a shedding phase? I am confident that the shedding phase is the transition to a greater good…as the weaker hairs fall out months later they are replaced by stronger, new hairs. My problem is that I am in the entertainment industry and will be starting a one month taping of a TV series from June 30th-July 30th of next year. I would like to have as much hair as possible by that time so would I be better off waiting to take the Avodart after the taping is complete, or should I start now and hope that the avodart will not cause a drastic shedding phase and help me stabilize the hair that I currently have? I guess this really comes down to a game of timing.

It will be 14 months since my HT when the taping starts in June so I am hoping that the transplanted hair will already be full by then. Also, most of the hair that I am losing is from the front hairline and temples. The crown seems to be doing ok.

Thanks again for your time and I would also be interested in undergoing a transplant with your team following the taping.

I really do not have a clear answer to your situation. In general, Propecia or Avodart will not be as effective on your front and temple areas. They each work best on the top/crown areas of your scalp. I do not know if you will have more or less shedding as everyone has different results, different side effects, etc. Shedding isn’t seen by all men that start the medication. Really, only time will tell and there is no clear way to predict this.

It would be interesting to know if Avodart did indeed change your sexual side effect issues, as I would expect that it would not make it better. There’s not enough reported about Avodart dosing in the treatment of hair loss for me to suggest that bi-weekly pills are the way to go.

Includes snippets from Wall Street Journal Article: Crucial to the hair-growth and balding process, scientists have found, vitamin D and the microscopic receptors that bind to it in skin as essential to good hair growth. These elements have become the focus for several research teams. (Supplements might offer health benefits for people lacking enough vitamin D, but they won’t bring back lost hair, researchers say.)

Some researchers, including those from the San Francisco Veterans Affairs Medical Center and Harvard Medical School, have identified molecules besides vitamin D that appear to activate the receptor and hold potential for future hair loss treatments. Japanese researchers demonstrated in animals that adding vitamin D helped the process of using stem cells to generate new follicles. Found in the Wall Street Journal — The Search for a Baldness Cure

My friend Dr. Richard Shiell commented:

“Plenty of sunlight and Vit D here in Australia (world’s highest rate of skin cancer). From my observation, our baldness rate and pattern-type is pretty much the same as elsewhere.

We are seeing Vit D deficiency in some Muslim women and children who cover-op and do not take advantage of our sunlight. I have not heard of any increase in hair loss. Kids at the beach these days are covered from head to knee as in the Victorian era so, if the author is correct, we should see more baldness in the future. I don’t believe it.”

It’s important to highlight the sentence from the article that states: “Supplements might offer health benefits for people lacking enough vitamin D, but they won’t bring back lost hair“.

In response to this news, some hair restoration doctors stated that they often recommend vitamin D as part of the treatment for women with balding or thinning hair. There does not seem to be a downside to this use, but I wouldn’t get too excited just yet about calling this a “cure”.

Tags: vitamin d, hairloss, hair loss, wsj