https://www.tandfonline.com/doi/abs/10.1080/09546634.2020.1782324?needAccess=true&journalCode=ijdt20
Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature
https://www.tandfonline.com/doi/abs/10.1080/09546634.2020.1782324?needAccess=true&journalCode=ijdt20
Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature
Background: Androgenetic alopecia (AGA) is a frequently encountered dermatological concern that impacts a patient’s self-esteem and quality of life. Finasteride is a selective 5-alpha reductase inhibitor that has been approved for the treatment of male AGA and the off-label use in female pattern hair loss (FPHL); however, its adverse effects may limit its use. Topical finasteride is a new formulation that aims to decrease complications caused by oral administration.
Objective: This review assesses the pharmacology, current therapeutic use, and safety of topical finasteride for the treatment of AGA and FPHL.
Methods: A PubMed search was conducted to include all English language articles on topical finasteride from January 1992 to January 2020.
Results: A total of 33 articles including 28 topical finasteride related articles and five AGA related articles were included in this review. Multiple studies on topical finasteride as the treatment for male AGA and FPHL showed positive results with a favorable safety profile.
Conclusions: Topical finasteride is a promising therapeutic option. We emphasize the importance of continued research for the establishment of a novel therapeutic agent.
I would say I’m a NW2 and have been looking into getting a hair transplant, preferably FUE. I have a consultation scheduled in a couple weeks but was just hoping anyone with experience could tell me what to expect regarding the cost. My temples are thin but not too noticeably with my hair style. My front hairline is just kind of uneven as well. I’ve been on Fin and Minox for over a year and I have had progress but I think it has plateaued.
If you are really have a Class 2 pattern and especially if you are under 25 years of age, it probably relates to the maturing of your hairline and not balding. A hair transplant would not be good in that situation. Send me photos to iwilliamrassman33@gmail.com and I will tell you if you have just a Maturing hairline
Generally, they live as long as the source hair where they came from. The donor area in the back of your head generally lasts your lifetime so when it is transplanted, it lasts our lifetime 98% of the time.
Exampe, those who can afford to). Is there some downside that is not apparent, which is why people bother with minox and fin?
A hair transplant is a careful decision not to be taken lightly. I tell my patients to take their time, wait until they are at least 26 and have the funds put away. Develop a good Master Plan for the hair loss as it evolves as hair loss is generally progressive for some men so even a hair transplant may have to be repeated to keep your hair appears up.
Hair loss victim spent six years and thousands of dollars on hair surgeries, and is still not normal nor has enough hair
I constantly warn consumers wishing to get hair transplants to find a doctor who cares about you, not the money you have in the bank. You can tell because a good doctor will develop a Master Plan for you which may or may not include a hair transplant. That doctor will measure your donor supply (an important metric) and give you an estimate on what your hair loss pattern might develop into over time and what you will have to do to keep yourself hairy. Here is a story that I commented from Reddit which is important for everyone considering a hair transplant to read: https://baldingblog.com/22-year-old-received-a-hair-transplant-of-2800-grafts-from-reddit/
It’s been 102 days since I first expressed my excitement about hopping on fin. Lots of very negative comments, some supportive. But after 3 and a half months, on propecia I honestly could not be happier.
Major diffuse thinning as well as obvious recession at my temples…have all gone!
My temples and juvenile hairline are about 50% restored, my hair hasn’t looked this good and thick in many years
Man #2:
24 male. Been on minoxidil since 1.5 yr and finasteride since 5 months. But all I’ve grown if thin baby vellus hairs. Will these ever become terminal
Man #3:
I’ve been on Fin (1mg) around 45 days now and I’m thinking about stopping. My libido is very low and I can get an erection but not fully hard. I’m only 20 years old so I want to take care of my sexual health not worrying about ED in the future. I’ve got a visual bald spot and my hairline isn’t great, I’m very self conscious about my hair and I really wouldn’t look good being bald. So I’m not sure what to do, is there anything I can do for my hair that doesn’t require me taking Finasteride?
During this shed i lost a lot of my eyebrow hairs i could pull out three to five at some times then one or two at others is this a sign that what i had was likely TE?
You need to be examined by a doctor as there are known conditions that cause what you are talking about
Started Fin 2 weeks ago. Side effects:
Increased libido (which the wife loves)
Increased confidence
More energy
I’m thinking these are probably just from the feeling of actually finally doing something about my hair loss. I used to get anxious multiple times per week thinking about the fact that I’m losing my hair. I was worried about fin sides after reading the posts on here, but I’m so glad I finally took the plunge. Instead of worrying about the hair I’m losing, I feel a sense of control and confidence. No negative sides at all so far.
I have heard this quite a few times.
During years me and my friends were balding and this year my friends went from diffuse thining to NW4/5 with a hairline. Even me before iv’e started Fin my hairloss went full speed in less then a year. From a NW1.5 to NW3 with crown thinning…
Does it always happen?
It all depends upon your genetics. Young men who inherit an advanced balding pattern usually get it by the time that they are 26 years old and will see the hair fall away rapidly starting somewhere between 17-21, Look at your parents family patterns (mother and father) so see what you might expect to see in yourself. Find a good doctor and build a proper Master Plan with that doctor to manage the hair loss if you are in this situation.
With male pattern baldness, large (terminal) hairs convert into small (vellus) hairs. This is the negative effect of testosterone and DHT, a potent testosterone derivative, on hair follicle stem cells. Despite lack of visible hair growth, hair stem cells remain largely intact in the bald scalp skin!
Human hair loss conditions result from abnormalities in the so-called hair growth cycle, the recurrent process of hair production separated by periods of inactivity. Current anti-hair loss treatments modulate only part of this cyclic process e.g., Finasteride lengthens hair production phase leading to longer hairs, but it cannot activate re-entry of dormant hairs into new growth phase. Because of this, such treatments show extremely slow and incomplete recovery from hair loss, especially when the condition is advanced. Additionally, the efficacy of new hair regeneration via stem cell therapy or the so-called hair cloning was never conclusively demonstrated in the clinical settings. Inspired by the naturally occurring human condition of excessive hair growth, UCI researchers have discovered that re-entry of dormant hairs into active growth cycle can be efficiently stimulated when hairs are exposed to a specialized type of pigment-producing cell or to the signaling molecules that this type of cell actively makes. This suggests that either transplanting cells into the skin or simply injecting their bioactive molecules is sufficient to drive new hair growth on the scalp.
UCI scientists also found that hair growth-inducing effect of pigment-producing cells is potentiated by other naturally occurring cells derived from blood. Moreover, they investigated the profile of secreted signaling molecules and determined that a wide range of skin specific cells, beyond pigment producing cells, can be coaxed to make them due to shared profiles of secreted factors. Injecting a synthesized cocktail of signaling molecules in to an area with dormant hairs in vivo in animal model induced rapid new hair growth. Prospective plans involve testing these effects on human skin. Targeting a signaling pathway for naturally robust hair growth in humans presents a promising approach for treating hair loss conditions.
The hairy nevus is a common, benign birthmark where vellus hairs convert into the terminal hairs normally found on the scalp. UCI scientists believe that this occurs because of a protein signaling molecule that is produced by the hairy nevus and UCI has identified key proteins that they believe is responsible for the hair growth.
The way UCI scientists will Microinject hair-growth promoting molecules, derived from the hairy nevus birthmark, into the scalp skin affected by male pattern baldness. The hope is that these molecules will act as a signal to dormant stem cells (as it happens in the vellus hair follicles of the hairy nevus). It is hoped that this will result in vellus-to-terminal hair transformation and a cosmetically desirable hair growth restoration in the balding male
The average head has up to 20% of the hairs miniaturized in the donor area and even in a non-balding man; however, in the balding area, I would expect to see a lot more miniaturization in the process of your losing your hair. Please send me microscopic views of your hair mapped against your head as shown here: https://baldingblog.com/mapping-out-your-balding/
In some people who reported initial sexual side effects, these effects went away in a few months. In others, it did not. If it persists, you should consider stopping it because there is a theory that in some of those people those who maintain long term side effects, they may get permanent sexual side effects.