I’m considering purchasing the Scalproller but i’m concerned as to the safety of the increased absorption of minoxidil. In your opinion do you think it is safe if the increased absorption is so much greater? And would using the Scalproller lead to a shed similiar to the shed when switching from 2% to 5% minoxidil?

The following response is by UK-based physician Dr. Bessam Farjo:

Response by: Dr Bessam Farjo United Kingdom

5% minoxidil is the safe limit. More may cause systemic side effects such as dangerously low blood pressure. It is speculated that the absorption of minoxidil in a lot of people is not as efficient as it could be. This is most likely due to method of application which can be influenced by the amount of hair present. I have prescribed 6% in the past without side effects and I know of a clinic in the UK that gives a 12.5% preparation! I don’t have any data with regards to their side effects. One possible side effect of too much minoxidil is a lowering of blood pressure and resultant light-headedness.

I don’t know if the scalproller will cause any shedding, but it will be one of the observations I will make when I start a clinical trial. I emphasise that at this point I see the scientific basis of such a device but cannot actually endorse the scalproller itself or support any claims that it will help with hair loss.

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Learn more about the author of this article, Dr. Bessam Farjo, on his BaldingBlog profile or at his website.

Hello, i am slightly confused, i read how resveratrol can increase test levels, is this true and would it worsen my hairloss?

But i also recently read a contradictory study on the combination of resvaratrol with curcumin, which is claimed to help with hairloss. Do you think this is a posibility? An italian company were seeking a patent on a pill that contained these two .

Also i take finasteride, can the res/cur, affect the absorption of fin? I take fin in the morning.

Here’s what I just learned from Wikipedia —
Resveratrol is a chemical produced naturally by several plants (including red grapes). As suggested, it gives the heart beneficial qualities of red wine. Curcumin is found in Indian spice turmeric, which is a member of the ginger family.

So in essence (let’s cut out all the nebulous scientific names), you want to know if natural extracts from grape and ginger can be beneficial to your hair. There are THOUSANDS of these natural concoctions people have tried to help with hair loss throughout history. I really do not know if it will work, but in the end it becomes a “buyer beware” market and your experience with how your body responds is the final answer you need for you. In my opinion, I doubt it will have an impact on your hair, but more so on your wallet and time. I don’t know anything about the study you’re referencing, so I can’t really give you any insight into their findings.

What is you opinion on the product Hair by Revitalash? Do you think it has potential as a hair loss treatment? I know you would have to be careful not to get it in your eyes.

This post gets two responses…

Response from Dr. William Rassman:

There is no proof that this product will work on scalp hair, although there are some doctors trying it with their own form of human experimentation. I will certainly let you know when there is a credible scientific study released. I spoke to a representative of the manufacturer and they are interested in learning if it has an effect on scalp hair loss but they have not begun testing it.

Response from Dr. Bessam Farjo:

Actually at the ISHRS annual meeting in Amsterdam 2 weeks ago, I (Dr. Bessam Farjo) presented some initial data from a study my centre is working on in collaboration with University of Bradford in the UK. Our work so far is on human hair in the laboratory, but there were encouraging results showing that Bimatoprost (the active ingredient in Latisse eyelash treatment) can make the hairs grow longer and faster and prolong the anagen (growing) phase. We also identified that there is a receptor for this compound in the hair follicles explaining its mechanism of action. Further work is ongoing and may in the near future result in a clinical trial that would show what value if any these medications have for scalp hair.

Since there’s obviously a ton of money in hair loss products, why hasn’t anyone done a conclusive study on the effects of saw palmetto on hair loss? It seems like if it’s believed to help, a conclusive study would (if it’s found to slow loss) help products containing saw palmetto off the shelves

I agree that a better controlled study would help us understand the impact of saw palmetto on hair loss, provided it was dose response oriented. The reason that this is probably not being done is that there is no patent coverage available for this drug, so when a study comes out, anyone can profit from the sale of the drug (in this case it is an herbal remedy not a drug). So there’s money to be made if it shows the herb is effective… but one company financing the study will potentially open the floodgates for other companies to profit. This does not make for a good business proposition if you were paying for the study. In other words, studies are not cheap and who is going to finance it if the money can’t be made back?

There have been limited studies on this very subject in the past. One such study from 2002 contained only 19 men. Of those men, 60% showed “improvement”, but I don’t know if that means their hair looked thicker, darker, or there was actually more hair. Plus, it was just a pilot study and too small to be worthwhile in proving effectiveness.

thanks so much for your work with this blog. i am 25, with what i would describe as a hairline that has receded about 1.25 inches at the corners and generally thinned in the front. i have been putting some thought into propecia’s timeframe lately, and would love to hear your thoughts on this.

merck of course has their (FDA approved!) literature, about what to expect after 3 months, 6 months, 9 months, etc…there are of course many variables that go into the whole equation, but what are your thoughts on the ratio of time an individual has taken propecia/total time the individual has experienced some degree of hairloss? i have been taking for just under 4 months now, and not really noticed anything. some people lose hair quickly, what has happened with mine has happened over 3+ years.

would you hypothesize there is a correlation between not only degree of hairloss and propecia’s effectiveness, but also between the amount of time that hairloss occured versus how long a person has been taking propecia? thanks!

There is a genetic test called HairDX Test for Finasteride Response that can check your overall sensitivity to DHT blockers like finasteride, as we are all different genetically. It scores a CAG repeat test, and when the patient scores low (less than 22, for example) they will have a better response from finasteride than when the score is high (above 22). In this way, it is possible to find out your overall sensitivity to these drugs (hence, effectiveness). Add this into the other variables you mentioned above, and you can get a more clear picture of what my happen to you over time, but the reality may not be as simple as just getting a genetic test.

The medical profession is at the doorstep of understanding genetic tests like this and fitting them into the course of patient’s balding patterns and the rate of the balding process. At 4 months, there is just not enough time to know how you will respond to the drug, but at a year or so out you may know more. Finasteride does not work as well in the frontal hair at reversing the process as it does in the crown. You can get yourself tested with this genetic test to anticipate your personal response to finasteride, but what you do with the information is not easy to ascertain. You will have to sit down with your doctor to explore the process further.

In all people, the effectiveness of Propecia over time will change because the balding process will change (it is progressive) and the degree of change varies with the individual. There are no rules other than what I discussed above, but I believe that as long as the balding person is taking Propecia, the drug is effective. To prove this, stop taking it and see that the hair loss just gets worse in a matter of months. Actually, I don’t advise you to try to prove it, because the cost in hair loss would be too great.