There has been some discussion on the Hair Transplant Network about the relationship between the amount of Epinephrine used during surgery and shock loss in the following months. I know that Epinephrine is used to control bleeding and constricts the blood vessels, but is it the main culprit in shock loss?
Shock loss is prevalent in younger men who are actively (rapidly) losing their hair. In simple terms, any shock to the weak/dying hairs will accelerate the hair loss. While we can hypothesize epinephrine as the culprit, it is probably a combination of the surgery itself, the drugs that are used, and where you are in the hair loss process that all contribute to shock loss.
Young men (under 28 years old) in rapid hair loss with unstable hair in the balding area are more likely to experience hair loss than older men (greater than 40 years old), regardless of the medications used. High doses of epinephrine, when used by less experienced surgeons, increase the risk of shock loss. Men on finasteride, on the other hand, are likely more protected against shock loss than men not taking this drug.
I suppose the one way to tell would be to inject epinephrine on one side of the scalp and saline in the other side of the scalp (without hair transplant surgery) to see if that causes shock hair loss. Any volunteers?