Could Propecia Be Used to Treat Cardiovascular Disease?

Doctor,

There is an established correlation between (early onset) androgenic alopecia and both cardiovascular disease and prostate cancer. Now interestingly, Propecia (more than likely) reduces the risk of prostate cancer. Since Propecia seems helpful against hair loss and against prostate cancer, could it also be helpful against the third correlate: cardiovascular disease?

At least some studies seem to consider DHT to be proatherogenic while others consider estradiol to be antiatherogenic (in men). Given the fact balding men carry an extra cardiovascular risk and prostate cancer risk, could finasteride not only reduce the risk of prostate cancer but work cardioprotective as well in this population? Unfortunately I did not find much empirical data (only one study – PMID: 12234510 – reporting a non-significant RR of 0.3). How plausible do you consider finasteride to be helpful in reducing the added CVD risk in balding (young) men?

A valid and interesting point. I honestly don’t know how plausible it is, but it is certainly a refreshing perspective from a sea of anti-Propecia campaigns and the paranoia of its side effects that I’ve been receiving via email lately.

Medications are not magic bullets. They have limitations and might not always work the way we think they should work, but there may be benefits as well as detriments (for those anti-Propecia fans) still undiscovered. After all, Propecia was an accidental discovery, but there is clearly a need to study the connection between heart disease on those men taking Propecia. Considering that many men on Propecia are young, the number of people needed for a valid study may be very high.