Dutasteride vs finasteride effectiveness (Updated 7/12/24)
I’m one of the countless who have started taking Dut and trying to figure out the best way to transition off of Finasteride to Dut daily. It seems that doctors and users do not agree on this topic. Some have suggested, and it seems in theory, that taking a loading phase of Dut is the best route since it takes 3 months of 0.5mg to reach steady state serum levels and possibly more at the tissue level. My current routine went from 1mg Fin to 0.5mg finasteride daily and 0.5mg Dutasteride daily. In theory, I’d do this for 3 months to not cause a shed from a medication gap, switch cold turkey, minimize simultaneous new medication shed, and stop fin shed. Since Fin binds to androgen receptors at the tissue level (scalp), and if finasteride is already binding to it all before dutasteride is introduced, does that prevent dutasteride from being able to bind to those receptors? And is it probably better to discontinue Fin and just keep doing dutasteride? People have great results when adding dutasteride 1x or 2x a week, which sounds counterproductive. In theory, thought would still leave Duta to block type 1 receptors, but fin still blocking type 2? I’ve seen, admittedly, just a few horror stories when people go up to 3x a week while using finasteride. They get better results once they go all in on one or the other. As much as I researched this, I’m still ignorant of how these drugs work at this level since most talk about its DHT blocking is usually blood /serum DHT and not at the scalp/tissue level.
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