Estrogen Inhibitor Novedex XT and Hair Loss

Dear Doctor:

Let me first state that I have had an obsession with my hair loss for some time. I have been on Propecia, Avodart, Revivogen and may others in the hopes of saving or regrowing my hair. However, I am an extremely thin male (40 years old) with very little muscle mass. I am now getting quite flabby around the gut with pretty severe love handles. I am a gym rat, going to the gym at least 4 days a week doing both cardio and resistance training. My diet is extremely clean. I am attempting to increase muscle mass and decrease my abdominal fat, but have had zero results over the past 2 years. I have discovered a product by the name of Novedex XT, which is an estrogen inhibitor. From the research I have done and the people I have spoken to who use it, they say it is the best product they have ever tried to gain lean muscle mass. There is a pub med article on it as well.I wish I could provide the link, but it doesn’t point to the page. The bottom line is that Novedex XT increases Testosterone, free testosterone and DHT levels significantly. My question is this, would continuing to use Avodart reduce the chances of DHT related hair loss? I assume the DHT increases because estrogen is inhibited and both total and free testosterone is increased. This is not an anabolic steroid that uses some “unknown pathway” to convert to DHT. So, if I were to continue using Dutasteride, would this offset the DHT related hair loss? Here is the article from pubmed:

Willoughby DS, Wilborn C, Taylor L, Campbell W.
Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798-7313, USA.

This study examined the effects of an aromatase-inhibiting nutritional supplement on serum steroid hormones, body composition, and clinical safety markers. Sixteen eugonadal young men ingested either Novedex XT or a placebo daily for 8 wk, followed by a 3-wk washout period. Body composition was assessed and blood and urine samples obtained at weeks 0, 4, 8, and 11. Data were analyzed by 2-way repeated-measures ANOVA. Novedex XT resulted in average increases of 283%, 625%, 566%, and 438% for total testosterone (P=0.001), free testosterone (P=0.001), dihydrotestosterone (P=0.001), and the testosterone:estrogen ratio (P=0.001), respectively, whereas fat mass decreased 3.5% (P=0.026) during supplementation. No significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones (P>0.05). This study indicates that Novedex XT significantly increases serum androgen levels and decreases fat mass.

PMID: 17460335 [PubMed – indexed for MEDLINE

Thanks!

I get questions like this all of the time. Playing with your hormones could very possibly do damage, as these are off label uses of these medications. You can not stop the negative effects of the hormone blockers with dutasteride or finasteride, but you trying to do it anyway. Maybe one day you will learn what you are doing to your body and realize that it can’t be good with estrogen blockers and pushing your testosterone high to get in shape and impact the blubber that you have around the middle. I don’t mean to sound rude, but why not do it the right way, which is a good exercise program with a professional trainer working with you on your routine and your diet?

I also gleam another question: Whether the estrogen inhibitor will increase DHT to the point that dutasteride is rendered ineffective. I don’t believe that is the way it works, as this is a competitive inhibition process between the drug and 5 alpha reductase. It will still compete effectively for the receptor.