Finasteride and Type I Collagen

Hello Dr. Rassman
Please tell me what is the effect of Finasteride on type I collagen (I think its the same which is found in skin) as stated in this study in simplified manner

Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia (PDF file)

thanks!

That is quite an article. I am not sure that I can extract the answer to your question from reading the article quickly. Those individuals with miniaturization seem to develop a thicker capsule to the follicular unit, but the effects of finasteride on this finding are not clearly stated in the article. The impact of DHT appears to be about 5 times more sensitive on the androgen receptor than with testosterone alone.

The study requires an astute understanding of the biochemistry of androgen receptor activity on the collagen in the dermis. I recommend the reading of this article for those scientists in the audience. I’m the wrong person to simplify this study, but if anyone else wants to contribute, please feel free to post a comment.