Have You Ever Seen a Case of Hair Loss Contained to a Just One Small Bald Spot?

Has a case ever occurred where a non uniform/asymmetrical form of hair loss had say thinning/hairloss centralized in a small area say 1inch x 2inch and the rest of your hair remained intact for the rest of your life?

Yes, there are inherited patterns like you mentioned and there are a variety of diseases like ringworm and alopecia areata that can do this. If that is a problem, see a dermatologist who can tell the difference for you upon an examination of your scalp and hair.