Is DUPA Caused By DHT?
i recently was browsing the internet looking for information about dupa and i came across this Canadian site which basically confirms DUPA is caused by DHT:
Diffuse Unpatterned Alopecia (DUPA)
DUPA is an uncommon variation of Androgenetic Alopecia in which the hair all over the head is sensitive to DHT and there is thinning everywhere. DUPA affects more women than men but the majority of women with AGA do not have DUPA. DUPA should be suspected if there are miniaturized hairs in the normally safe donor area. Hair transplantation is not an option for DUPA because there is no safe long-lasting donor hair.
I have my doubts that DHT is the cause of DUPA (diffuse unpatterned alopecia). I believe that there is a strong genetic influence behind DUPA, but if it was caused by DHT, it would be responsive to drugs like finasteride (Propecia) or dutasteride (Avodart). I have tried both on patients and the response has been very poor. So at this point, I will have to respectfully disagree with the opinion that DHT causes DUPA.
The typical female diffuse alopecias that impact all of the hair (including sides and back of the scalp) are not DUPA, but a genetic process which happens to have the same pattern (phenotype) as DUPA in males. It also does not respond to these drugs.
As I have mentioned in earlier blog posts, medicine is a descriptive science that often does not give us much insights to the cause of what we are seeing.
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