Minoxidil Sulfate vs Regular Minoxidil

Dear Doctor,

I want to start using minoxidil to help with hairloss. I was reading as much as I could about it, including every entry on your site.

While reading about minoxidil on the web, I came across companies utilizing a different form of minoxidil in their formulas called “minoxidil sulfate” which is supposed to be much better than regular minoxidil.

A search for minoxidil sulfate pulled up the following study on PubMed apparently from research done by UpJohn:

“An important step in understanding minoxidil’s mechanism of action on hair follicles was to determine the drug’s active form. We used organ-cultured vibrissa follicles to test whether it is minoxidil or its sulfated metabolite, minoxidil sulfate, that stimulates hair growth. Follicles from neonatal mice were cultured with or without drugs and effects were assessed by measuring incorporation of radiolabeled cysteine in hair shafts of the treated follicles. Assays of minoxidil sulfotransferase activity indicated that vibrissae follicles metabolize minoxidil to minoxidil sulfate. Dose-response studies showed that minoxidil sulfate is 14 times more potent than minoxidil in stimulating cysteine incorporation in cultured follicles. Three drugs that block production of intrafollicular minoxidil sulfate were tested for their effects on drug-induced hair growth. Diethylcarbamazine proved to be a noncompetitive inhibitor of sulfotransferase and prevented hair growth stimulation by minoxidil but not by minoxidil sulfate. Inhibiting the formation of intracellular PAPS with chlorate also blocked the action of minoxidil but not of minoxidil sulfate. Acetaminophen, a potent sulfate scavenger blocked cysteine incorporation by minoxidil. It also blocked follicular stimulation by minoxidil sulfate apparently by directly removing the sulfate from the drug. Experiments with U-51,607, a potent minoxidil analog that also forms a sulfated metabolite, showed that its activity was inhibited by both chlorate and diethylcarbamazine. These studies show that sulfation is a critical step for hair-growth effects of minoxidil and that it is the sulfated metabolite that directly affects hair follicles.”

I found a few companies such as Sinere that use this form in their Nanominox and DS Labs which uses it in their Spectral DNC.

My question is….if this form of minoxidil is “14 times more effective” than regular, according to UpJohn’s own studies, do you have any idea why they don’t use it in their own Rogaine products? Also, do you think I would be better off using this form myself?

I cannot find anything impartial written about this compound, so anything from you, hopefully detailed, would be greatly appreciated.

I do not have a good answer to your question, but the study (which is nearly 2 decades old) that you are referring to was done on neonatal mice, not humans. I would think there are some differences between mice hair and human hair. Being that the studies are from the late 80s/early 90s, I’d make the leap and assume that if the minoxidil sulfate were to be that much better than regular minoxidil (and with no greater side effect potential), that there would be a new product out by now using it. The FDA has approved standard minoxidil in 2% and 5% concentration, and both are available for over the counter sales (no prescription required).

If you know of a product that uses minoxidil sulfate, I suppose you can give it a shot — I’m not by any means recommending it (I like to stick with the medications proven safe and effective), but if you don’t mind being a guinea pig, I’m sure visitors to this site would love to hear about the results.