I’m 14 and look at my hair, it is falling out big-time. I have met with 2 doctors so far and no doctor has given me a reason or a treatment
A nasal spray that blocks the absorption of the coronavirus completely protected ferrets it was tested on, according to a small study released Thursday by an international team of scientists. The study, which was limited to animals and has not yet been peer-reviewed, was assessed by several health experts at the request of The New York Times.
If the spray, which the scientists described as nontoxic and stable, is proved to work in humans, it could provide a new way to fight the pandemic, with a daily spritz up the nose acting like a vaccine.
“Having something new that works against the coronavirus is exciting,” said Dr. Arturo Casadevall, the chairman of immunology at the Johns Hopkins Bloomberg School of Public Health, who was not involved in the study. “I could imagine this being part of the arsenal.”
The work has been underway for months by scientists from Columbia University Medical Center in New York, Erasmus Medical Center in the Netherlands, Cornell University and the University of Campania in Italy. The study was funded by the National Institutes of Health and the Columbia University Medical Center.
The spray, which attacks the virus directly, contains a lipopeptide, a cholesterol particle linked to a chain of amino acids, the building blocks of proteins. This particular lipopeptide exactly matches a stretch of amino acids in the spike protein of the virus, which the pathogen uses to attach to a human airway or lung cell.
Before a virus can inject its RNA into a cell, the spike must effectively unzip, exposing two chains of amino acids, in order to fuse to the cell wall. As the spike zips back up to complete the process, the lipopeptide in the spray inserts itself, latching on to one of the spike’s amino acid chains and preventing the virus from attaching.
“It is like you are zipping a zipper but you put another zipper inside, so the two sides cannot meet,” said Matteo Porotto, a microbiologist at Columbia University and one of the paper’s authors.
The work was described in a paper posted to the preprint server bioRxiv Thursday morning, and has been submitted to the journal Science for peer review.
Ferrets are used by scientists studying flu, SARS and other respiratory diseases because they can catch viruses through the nose much as humans do, although they also infect each other by contact with feces or by scratching and biting.
The protective spray attaches to cells in the nose and lungs and lasts about 24 hours, Dr. Anne Moscona, a pediatrician and microbiologist at Columbia and co-author of the study.
“If it works this well in humans,” she said, “you could sleep in a bed with someone infected or be with your infected kids and still be safe.”
You may be brushing or combing to roughly. Use a wide tooth comb or brush and see if that changes things.
I’m 34 and have been using min and niz for about 10 years. Honestly they did their job in maintaining and even regrowing a bit of my hair pretty well but I can see my hair is starting to thin out a bit on top. More of my scalp is visible. I ordered some cheap generic brand of fin called Accord (hopefully its legit) but after reading this forum I’m having second thoughts. My sex drive isn’t that high as it is and the side effects seem brutal. Is there anything I should know before starting these pills or should I just not bother?
Thanks in advance for any advice
Finasteride is a lifetime commitment so if I were you, I would try to get a HAIRHCECK test (https://baldingblog.com/haircheck-test-how-it-is-done-video/ ) before starting the drug to be absolutely sure you know where your hair loss is starting from.
You switch recently from Proscar divided into quarters to the generic one mg finasteride and saw an immediate effect suggesting that the genetic had something wrong with it. I suggested that you switch to the brand name Proscar and the divide it into quarters. That will get rid of the genetic variability
Some men are very sensitive to finasteride especially in the crown as shown in this man
This is an interesting approach to making topical finasteride by using minoxidil to essentially dissolve it into solution as discussed here: https://www.getfreshman.com/learn/can-you-make-your-own-topical-finasteride/
I have no experience with this and do not know if it will work so I can’t give an opinion on it. This link seems to be passing from person to person on the internet. Anyone with experience with it, please contact me.
The traditional compounding pharmacies do not approach it this way. They often create a liposomal formulation which keeps the drug at the skin level and doesn’t let it go into the body. I know that minoxidil is often absorbed into the body from skin applications alone, so I would suspect that the same would occur with finasteride dissolved in the minoxidil solution.
Finasteride and minoxidil have been used for 3 months with good results; however, this man has not shown comparable photos so it makes the case less compelling
Would you extract hair outside the safe zone, right at the lowest point of the nap if the patient said he knew it may not last but wanted a more even looking donor area, post-extraction?
I would argue with the patient in his favor, explaining two elements of using neck hair, (1) neck hair is not permanent and (2) the area scars worse than other parts of the scalp and without hair, the scars will show.
These are very nice results, especially in the crown which is more predictable. The frontal hairline is starting to grow out as well.
I’ve been taking fin since August. Lately I’ve been noticing that I’ve been experiencing memory loss… Like if a prof tells the class something important, I might not recall what it was if I don’t take any notes. I also feel as if words come slower to me. I’ll lose my train of thought so easily!
I could just be crazy. Or I could be sleep deprived. Stressed. Idk. I’m in grad school and I read a lot…like I’m able to complete my assignments well, but I feel like I just lose my train of thought sometimes and words come slowly sometimes. Also I’ll forget certain things that people say.
Maybe I’m crazy! This could just be normal…like people don’t always retain everything they hear, and sometimes people don’t think clearly for whatever reason.
Brain fox is a rare but significant complication of finasteride. You described it perfectly. You should speak with your doctor to find out if you should stay on the drug
I’m going to start the Big 3 to at least TRY for some regrowth. As a 33 year old NW6 I don’t have much to lose. I do have a ton of minituarized hairs on my crown, so it’s worth a shot I suppose. My results over time would be connected with a hair transplant. Unfortunately, topical minoxidil doesn’t work for my lifestyle, so I want to try Oral Minoxidil, and switch to topical down the line. I’ve heard of some potentially dangerous cardiovascular risks associated with oral Minoxidil. I consider myself relatively healthy, with normal BP levels, although I haven’t had a physical in several years. Should I consult with a doctor prior to ordering oral minox? Or would a low dose (0.25-0.50 per day) be OK to start?
Get a good doctor and don’t be your own doctor here.
On a proscar 5mg split into 4 from Walmart pharmacy. This latest drug has got me horny as fuck. Not sure why, but I’m always thinking about sex and my pecker is pointed straight up most of the time. WTF. Can some of y’all pass on your ED pls
I have had this complaint from some of my patients, including one of my sons. He just learned to have more sex.
This is an unusually fast response to finasteride and dutasteride. I suspect that he would have had the same response from either medication alone.
I’ve been following my hairloss for over a year, I first though my hairline was receding. But my hairline itself has stayed in a similar position for over a year. But I’ve been shedding alot over the past few months. In August I hopped on fin. I didn’t know if it was MPB (Diffuse Thinning) or Telogen Effluvium, but I’ve been treating it as MPB incase it is. So I’ve been using fin (1.25mg) everyday and Nizoral weekly. No side effects btw.
I feel like my shedding has slowed, if it was TE, it would be slowing around this time too, but I don’t know if it placebo. But I’m losing hair on the side of my head too, if it was MPB I shouldn’t be losing hair here right?
When I got my prescription for fin, both my derma’s said I wasn’t losing hair (it looked decent then, now my hair loss is more visible). I will go back and ask them again, but wasn’t possibilities of what is causing this, since I had to suggest fin myself.
You should get miniaturization analysis of your donor area (see: https://baldingblog.com/do-i-have-dupa-diffuse-unpatterned-alopecia-photo/ ). You can get this by purchasing this instrument and sending me photos: https://www.amazon.com/Celestron-LCD-Handheld-Digital-Microscope/dp/B004IANQNQ/ref=sr_1_14?keywords=celestron+microscope+camera&qid=1570126460&s=gateway&sr=8-14
