You need a good examination by an expert. You still have your widow’s peak. Also, I noticed the changes on your right side, suggesting that you took some medication to reverse your 2021 balding. This is not valuable to me as you are not giving me the information I need to help you.
Hi, I’m a South Asian 17-year-old female. When I was younger, I had incredibly thick and healthy hair. However, over the past 1-2 years, l’ve noticed a significant amount of hair loss. My middle part has widened, and overall, my hair is much thinner now. I’ve attached pictures comparing my hair now versus a few years ago. Lately, it feels like I’m losing more hair than normal on a daily basis. I recently got a blood test done, and it showed that I’m very low on iron. As a result, l’ve started retaking my vitamins, including iron and biotin. A few days ago, I ordered castor oil and Mielle rosemary oil, and they arrived today. I heard that you’re supposed to dilute the Mielle rosemary oil, so I mixed it with castor oil. Before applying it, l massaged my hair with a silicone massager for about 5 minutes. However, after applying the oil mixture, I noticed a lot of my hair fell out. Is this normal when starting hair oiling, or am I doing something wrong? Also, if there’s anything else I should be using or doing to help grow back my hair, please let me know. Thank you.
You should be seeing a good hair doctor to diagnose you. You should look for deficiencies in Iron, Vitmin D, anemia, and other blood tests. Is there anyone in the female side of your mom’s or dad’s family that had hair thinning at any age, particularly at your age? Your hair seems to have considerable miniaturization. You need a good microscopic examination by an expert as part of a doctor’s evaluation of your hair loss.
[If you have any questions, you can reach me at williamrassman33@gmail.com]
I (24M) have had hair loss for almost 3 years now. You can see the current state in the pictures. It’s uncomfortable for me to go out, and when I do, I only go out wearing a cap. I’m really not a big fan of medication, which means I would prefer to avoid finasteride. Would you advise me to have a hair transplant? How many grafts would be used? How long would it last until I have to get another one? If Finasteride is the only way out, would it fill my receding hairline with hair again? I don’t know what to do and it’s really stressing me out
You must recognize that hair loss is a progressive process until you reach your final genetic pattern of baldness. The single photo shows thinning in the frontal hairline with a possible forelock and balding around the forelock. I would need better photos to give you an opinion. There is also a suggestion that you have miniaturization throughout your scalp, which, if I am right, is a bad omen. Finasteride is the single best drug for reversing miniaturization and works best for men under 25. A hair transplant would be a disaster for you because if you have extensive miniaturization, you would likely develop hair transplant shock loss after a hair transplant. See a good doctor or get a consultation from me at williamrassman33@gmail.com
[If you have any questions, you can reach me at williamrassman33@gmail.com]
I started losing my hair at the age of 18 in 2020, as soon as it was noticeable I decided to shave it off with a machine. But last year, in December, I decided to let it grow because I wanted to have it evaluated by a doctor, I let it grow for 4 months. And here is the thing, I realized that my hair was falling out a lot, I was probably losing between 100-200 hairs a day, every time I woke up I could easily see 30 hairs on the pillow, my hair was falling out just by pulling it or passing my hand through my head. I had the appointment and shaved it again, however, I noticed that my hair is no longer falling out and that there is no more hairs on my pillow, so my question is, is it possible for the hair to only fall out when it reaches a certain length? Or is this BS?
Normal hairs grow at a rate of 1/2 inch per month, and for a man in his early 20s, it probably would grow for between 2-3 years. These hairs can fall out if you have the genetics for hair loss. Some hairs become miniaturized, and they will not grow to their full length, shortening over time until one day these miniaturized hairs will fall out; cutting them short will not change the hair loss cycle and the loss that I discussed above; sorry to burst your bubble.
I don’t know your age, but from seeing these photos, I think you have far more miniaturization than this photo shows, possibly in the frontal hairline. You need to be examined by a good doctor with a trichoscope. Then you should go on ORAL finasteride first, as this is the best medication for most people who have extensive miniaturization.
[If you have any questions, you can reach me at williamrassman33@gmail.com]
The photos have arrows pointing to an area of his head, which shows miniaturization in three different phases of development. The hairs that have lost their pigment are the earliest of these miniaturized hairs, and the one on the right is far more advanced. As you can see, the shaft thickness is very skinny.
Click to Enlarge
Ive been noticing my hair thinning over the past year, but believe Ive caught it early. I used to have a very thick head of hair but it has started to thin roughly a year ago that I can see my scalp a lot when its wet. Feeling a bit concerned, Im considering finasteride daily. Will this help increase the density and thickness of my hair or should I opt for minoxidil?
You have clear frontal early thinning, which may lead to balding. You should not overthink this. Finasteride is the best drug if you are under 25 to reduce this frontal thinning. If that doesn’t work, oral minoxidil might be your next step. At any time, you can try microneedling with a Dr. Pan device with 36 needles and a depth of 1.25mm once a week but I hope that the finasteride will work for you.
Merck manufactures both medications, and they are the same except for dosage. Finasteride also comes in generics for a fraction of the cost of Propecia. For example, Costco sells a year of finasteride (generic) for $30, while some other pharmacies charge hundreds of dollars for the same drug. Compare the 5mg Proscar to the 1 mg Costco generic and then talk money with us.
http://www.snuh.org/global/en/about/newsView.do?bbs_no=4711&
[If you have any questions, you can reach me at williamrassman33@gmail.com]
I read this article, and it only addressed mouse studies. It is a long way from here to human use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678755/
Please note the following statement in the article:
” Since the original introduction of low-dose oral minoxidil for this indication, reported adverse effects have been purported to be infrequent and of minor impact, with 15.1% hypertrichosis, 1.7% lightheadedness, 1.3% fluid retention, 0.9% tachycardia, 0.4% headache, 0.3% periorbital edema, and 0.2% insomnia reported in the largest retrospective multicenter study so far of 1404 patients, leading to drug discontinuation in 1.2% of patients.”
The focus on the Pericardial Effusion is significant as it appeared in a woman with a low dose of 1.25mgs/day. So the kew here is to watch for the following symptoms as they appear:
Shortness of breath, discomfort while breathing in the supine position, chest pain, lightheadedness, and swelling in the legs
Any medication can have serious side effects. Aspirin for example, has killed people from allergic reactions, bleeding from long term use, etc.. For those of you who take oral minoxidil, just be alert to the warnings in this article.
I was wondering if I should stop taking my oral minoxidil dose of 1.25mgs/day/
[If you have any questions, you can reach me at williamrassman33@gmail.com]
If you are worried about it, or if you had periods of light-headedness, or if you had rapid heart beats from the oral minoxidil, skipping a daily dose will have no negative impact on your hair.
I lost my crown hair and got transplants and SMP. My genetics didn’t impact my frontal hairline. I was lucky
Amplifica’s AMP-303 Study
Unveils New Hope for Hair Loss
Treatments
NEWS PROVIDED BY
Amplifica Holdings Group, Inc.
Sep 30, 2024, 09:02 ET
First-in-Human Trial Demonstrates Promising Results for the Treatment of Androgenetic Alopecia SAN DIEGO, Sept. 30, 2024 /PRNewswire/ — Amplifica Holdings Group Inc. (“Amplifica”), a privately held clinical-stage biopharmaceutical company, today announced results from its first-in-human trial of AMP-303, a novel intradermal injectable treatment for androgenetic alopecia (AGA), the most common form of hair loss. The randomized, double-blind, placebo-controlled, multicenter study was designed to evaluate the safety and tolerability of AMP-303, while also evaluating its efcacy. The results suggest that AMP303 has a significant potential to address hair loss after one treatment cycle.
The trial enrolled male participants aged 18 to 45 diagnosed with AGA, and stratified subjects based on the duration of their hair loss. The study divided participants into two distinct groups: those with recent onset of hair loss (3-5 years) and those experiencing more long-standing hair loss (over 10 years). A bilateral paired treatment design in the frontal temporal region was used, where each participant was randomized to receive AMP-303 on one side of the scalp and a placebo on the other, allowing for a direct comparison within individuals. This approach, combined with subject stratification by onset of hair loss, allowed for the analysis of AMP-303’s potential efectiveness across diferent timepoints and stages of hair loss while controlling for individual variability.
Key Study Findings:
“The ability to demonstrate measurable improvements in hair regrowth with just one treatment cycle is a breakthrough in addressing androgenetic alopecia,” said Frank Fazio, President and CEO of Amplifica. “The success of the AMP-303 study not only validates our approach but also sets the foundation for advancing additional programs in Amplifica’s pipeline. With this momentum, we are excited to to accelerate the development of new therapies targeting hair regeneration, reinforcing our commitment of developing novel treatments to address androgenetic alopecia.”
William Rassman, MD, a pioneer in hair restoration surgery and Amplifica co-founder, added, “The results observed in the frontal temporal region are particularly encouraging, as this area has traditionally been one of the most challenging to demonstrate a clinical response. AMP-303’s potential to stimulate hair regrowth in this region underscores its unique potential and sets it apart from existing therapies. Findings from this initial clinical study ofers renewed hope for patients struggling with hair loss that have historically been resistant to treatment.”
With the results from this first-in-human study, Amplifica is poised to advance AMP-303 through additional clinical trials to further explore its therapeutic potential for both men and women sufering from hair loss. The company aims to develop AMP-303 as a highly diferentiated option in the hair loss treatment landscape, which is currently limited to daily-use topical and oral therapies.
About AMP-303
AMP-303 is a proprietary, innovative formulation specifically engineered for intradermal injection to target androgenetic alopecia (AGA). Designed to stimulate hair regrowth, AMP-303 has undergone extensive pre-clinical development, including the detailed identification and understanding of its mechanism of action. Proof-of-concept testing in xenograft models has demonstrated its powerful hair growth promoting properties, laying the groundwork for its potential as a transformative treatment. Complementing this scientific advancement is a robust intellectual property portfolio, securing the innovation behind AMP-303 and reinforcing its promise as a groundbreaking solution for individuals sufering from AGA.
About Amplifica Holdings Group, Inc.
Amplifica is a rapidly emerging biopharmaceutical company focused on developing novel treatments to address androgenic alopecia (hair loss), a condition estimated to afect over 50 million men and over 30 million women in the United States alone. The Company is taking a nature-inspired scientific approach using a molecular mechanism that regrows natural hair. The Company has identified and isolated unique signaling molecules that stimulate hair follicles to regrow hair. Amplifica will be initiating product development programs and clinical trials to evaluate the safety and efcacy of its core technology as well as obtaining all applicable regulatory approvals.
For more information, please visit https://amplificabio.com.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words such as “anticipate,” “believe,” “contemplate,” “could,” “estimate,” “expect,” “intend,” “seek,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “target,” “aim,” “should,” “will,” “would,” or the negative of these words or other similar expressions. These forward-looking statements are based on the company’s current beliefs and expectations. Forward-looking statements include, but are not limited to, statements regarding the potential efficacy of the Company’s product candidates, the Company’s expectations with respect to development and commercialization of the Company’s product candidates, the initiation or completion of any future clinical trials. Actual results may differ from the forward-looking statements expressed by the Company in this press release and consequently, you should not rely on these forward-looking statements as predictions of future events. Forward-looking statements contained in this announcement are made as of this date, and the Company undertakes no duty to update such information except as required under applicable law.
Amplifica’s AMP-303 Study Unveils New Hope for Hair Loss Treatments 9/30/24, 6:08 AM
Contact:
Company
info@amplificabio.com
Media
EvolveMKD – Amplifica@EvolveMKD.com
SOURCE Amplifica Holdings Group, Inc