There seem to be changes in the brain in people with post-finasteride syndrome (PFS)

We have known for some time that finasteride can alter brain function in some people as we side effect in a few patients that change mood.  This article points out a mechanism in those patient with Post-finasteride syndrome (this is a very, very small subset of people who take finasteride, possibly less than 1:1000 people). Despite these findings, nobody knows whether there is a causal relationship with Finasteride, especially it would be interesting to know if depressive or other patients have similar findings.  You can see these same brain changes in stressed-out OCD or panic disorder patients who are decompensating and have never taken finasteride. The message here, is be careful how you interpret these findings.

https://www.sciencedirect.com/science/article/pii/S0960076017301024