Type I DHT Is Found in the Human Brain?

Dutasteride is three times more potent than finasteride inhibiting the type II enzyme and 100 times more potent than finasteride inhibiting the type I form of the DHT producing enzyme. Dutasteride is not approved by the FDA for the treatment of Male Pattern Hair Loss and is approved at a dose of 0.5 mg a day for the treatment of prostate enlargement. While both the type I and type II enzymes are found in the hair follicle, there is a recent study which shows that type I is present in the human brain. The function of this enzyme in the brain is still unclear.

Would you say that finasteride is clearly the better option as it doesnt block the type 1 enzyme that is present in the human brain. Also Dr.Rassman would you say that the chances are that the messages you have got from people saying they are loosing their wit and stumbling over their words are true. Their is clearly a link between a drug blocking an enzyme thats present in the brain and brain related symptoms such as stumbling over words and loosing their wit.

I really do not know anything about the brain impact of DHT blocking medications and I certainly can not place cause and effect together. Your questions are good, but most of the work in this area is done in animal models which may not extrapolate to humans. What you think is clear, I think is not. More research needs to be done before I could answer your question with any confidence.