Waking up dormant hair follicles with Vixarelimab
Researchers have found that a molecule called «oncostatin m» is what keeps the hair follicles in a dormant stage.
Vixarelimab is a drug that is supposed to be used for a skin condition called Prurigo nodularis. It is a oncostatin m receptor blocker. My theory is that this drug can block the oncostatin m molecule which comes from JAK-stat5 signalling. And thus it may «wake up» the dormant hair follicles.
Oncostatin M blockade with vixarelimab were supposedly well tolerated and no adverse effects were found under clinical trials.
When a hair follicle ‘wakes up’ from its normal sleep cycle (teolgen), it requires certain signaling molecules to kick start the stem cells that create the anagen hair growth. Many researchers believe that the absence of an important signaling molecule that is genetic, is what causes genetic patterned hair loss. This is clearly a different explanation than you have proposed. Your idea would have to be tested in animal models and human clinical trials if indicated after the animal studies are done successfully.
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