What Role Does DHT Play Besides Hair Loss?
Hello Mr. Rassman,
I have two questions regarding hairloss. First one is, what is the role of the DHT in human body other than attacking hair follicles? I mean male human body (as far as I know women produce DHT too but very low, I am sorry If I am wrong) produces that so I assume it must have some beneficial effects too. Can you explain the other effects of DHT please?
My second question is regarding the type I and type II a.reductase enzyme. Based on what I did read finasteride inhibits type II, and dutasteride inhibits both type I and II. is it necessary to inhibit type I as well to prevent hairloss? Based on my knowledge it is unnecessary to inhibit type I, am I right with my opinion?
Thanks for your time, I appreciate that. Best Regards
Dihydrotestosterone (DHT) is produced by the body as testosterone is broken down in the normal course of your overall metabolism. As testosterone is also produced in women in smaller quantities, it will break down (be metabolized) just the same as in men. DHT for males is involved in the descent of the testes in fetuses, some of the maturing factors in adolescence like changes in voice, changes in hair character, underarm and pubic hair in both sexes, and the appearance of body hair as we get older (including the beard). For those men who are beyond 50 years old, it produces nose and ear hair as well… so there’s something to look forward to.
With regard to your second question, you are right. The role of type 1 5AR is poorly understood, but does not seem responsible for hair loss.
Type I DHT has also been found in the hair follicle, and though it may not play an as prominent role as Type II in MPB, the stronger dutasteride clinical results indicate that they aren’t only achieved by the additional suppression of Type II DHT, but the dual inhibition of both.