Long term finasteride use (extracted from today’s Reddit.com)

This is an extremely complete assessment of the long term use of this controversial drug. The writer concludes that adding minoxidil and microneedling will increase the benefit and I agree with that conclusion.

Information on Finasteride Dosage and Long term Efficiency

Hi everyone I previously made a post about the ultimate hair loss protocol, the post consisted of the best treatments of hair loss and mainly debunking some finasteride risks. However today I will be discussing finasteride importance in people’s protocol, dosages, and long term efficiency. Before I get into the niddy griddy lets get one quick point out of the way

  1. For the vast majority of people, testosterone levels in the normal range (400-1100ng/dl) will have very minimal effect on hair loss, and there have been some theories and studies going around that having optimal T levels in the natural range, Optimal T/DHT ratios, and nonexcessive body fat, can help hair loss. Most people PRONE TO HAIR LOSS will probably lose hair quicker when being high body fat and low t levels, then compared to if they were a lower body fat (under 18%), and high natural range T levels. Now don’t misinterpret what I am saying, thinking becoming healthier will cure hair loss, or help it in an extreme way. Nope, there is gonna be a guy out there 300 pounds eating burgers all day and will have a NW 1 at 50, it’s genetics my friends, other then a few rare deficiency and hair thinning from hyperthyroid, almost all your hair loss is from your genetic makeup, specifically, your scalp sensitivity to DHT. Dereck from MPMD did an experiment before bringing his t levels to 2000 ng/dl and using dutasteride, he reported experiencing hair loss, ( didn’t, seem to be extremely noticeable), however, all his experiment really proved was that testosterone above the natural range can cause hair loss, but most of us will not be having our T levels that high.

Now let’s begin with finasteride.

https://preview.redd.it/eh5l730uafd51.png?width=841&format=png&auto=webp&s=456aff6a2c99eb95bb20c14063821875f3bc4054

As you can see above is the 5 year study of finasteride 1mg a day consisting of 4 different groups. Some interesting things to notice

  1. The placebo group demonstrated an increased rate of hair loss from year to year, playing into the theory that our androgen sensitivity goes up as we get older, or something else that is causing an increased rate of hair loss each year.
  2. The validity of the statement that starting finasteride earlier is clearly shown above, showing that starting a finasteride year later, did not catch up to the group that was finasteride the entire time. BASICALLY START FIN NOW THEN LATER.
  3. The group that went off finasteride after one year, went down to the same spot as the placebo group after one year. However, after going back on finasteride, the group reached to almost the same position as the group that was on finasteride for the entire study. So it seems the reports that taking a break from finasteride after using it for seemingly a year or above, will not hurt your gains to a noticeable degree and possibly changing some factors to your scalp which are the slightly permanent or delayed benefit after stopping use of finasteride.

Now based on the people on finasteride for all 5 years, we can use simple math to predict long term efficiency of finasteride, which can also be back up with a study that I will demonstrate after.

So we will take the highest finasteride hair count, which is after one year on average. Based on multiple studies I took the average hair count after one year to be (80) on 1mg per day, also using this number to be conservative. We know the hair count change from baseline after 5 years was (38), So using these two points including the years we can create a formula to calculate the efficiency of finasteride. Again note this is just an estimate

(1,80), (5,38)

y= -10.5(x) + 90.5 *x is the year on finasteride and calculation result is hair count, estimate not exact

So based on this formula using the data above after 10 years we can estimate that the average man on only finasteride will be -14.5 below the baseline. Again you may be higher, while some are lower, that is just the average. Now compare this to the placebo group which the information found online the average loss after a year from baseline is -15 (imagine 10 years on finasteride is equivalent to one-year placebo for the average man….crazy), now after 5 years the placebo group was -239 below baseline, so again let’s do some calculations.

(1,-15),(5,-239)

y= -56(x) + 41

That means after 10 years of no finasteride the average hair count is a staggering -519 below the baseline.

The group starting finasteride after one year of being in the placebo group.

(1,50), (5,4)

y= -11.5(x) + 61.5

For this group after 10 years we have a hair count of – 53.5, this is equivalent to about two years without finasteride in the placebo group.

Again above is considered a worst-case scenario since two studies have been published on finasteride, with the duration of finasteride use being 10 years, demonstrating that finasteride either increased or stabilized hair count in 86-91% of patients. So the calculation above should really be giving you the worst case result, which is still great, showing finasteride being great for stabilizing hair loss for many years. Also consider this is just finasteride, no minoxidil, dermarolling, alfatradiol, RU, and CB.

Now for finasteride dosage.

Fuck the dosage curve. yes, the one I am showing you below,

https://preview.redd.it/jfzx3tbwafd51.png?width=622&format=png&auto=webp&s=a6c9e33255b487d796357e287b9546eff492780b

This graph tells me absolutely nothing, just how much DHT is being inhibited, great, but what you and I care about is hair growth, stabilization, cost, and side effect free profile.

Based on this graph it should make no sense why lower dosages work for some people, in terms of side effects being alleviated.

Based on hair count after one year

https://preview.redd.it/cjyngqaxafd51.png?width=505&format=png&auto=webp&s=6683b30eeb9418a005805fc6e9b10b4ac57cbf18

1mg inhibits exactly the same amount of DHT as 5 mg yet 1 mg is 80-90% (Based on a couple of studies). 5mg is shown to have a higher side effect profile compared to 1 mg, even though they inhibit the same amount of DHT. 0.2 mg daily is 80% as effective a 1 mg, yet it only inhibits 3-7% less DHT. So again DHT levels do not seem to matter in terms of side effects and efficiency, or they are not entirely correlated. So many people on the site are wondering what the most cost-effective dose as well as side effect free profile. Well for starters we want to at least take finasteride on a regular basis meaning every day, every other day, or 3 x a week. So assuming 1 mg is the gold standard lets calculate using the info of 0.2 vs 1 mg hair count. We will use the total weekly amount of each so 7 mg a week vs 1.4 mg per week.

(1.4,61), (7,77)

y= 2.86(x) + 57 (x being the weekly dosage)

So if you take 1 mg (3x a week) that would mean your hair count would be 65, then there is 1.25mg 3 times a week will give you a hair count is 68. So you get the point, there are diminishing terms. In technical-scientific terms no 3 x 1mg a week is not as good a 1mg daily, however the difference is minimal, and if lowering your dosage allows you to take finasteride side effect free, which seems to be dose-dependent, please lower your dosage, knowing that finasteride is used for stabilization and that using things like minoxidil and derma rolling should be used for major hair regrowth.

Hope you enjoyed the post. Have a good day

The actual text with good graphics can be found here:  https://www.reddit.com/r/tressless/comments/hyv2fg/information_on_finasteride_dosage_and_long_term/

Get a virtual consultation with Dr. William Rassman and Dr. Jae Pak for hair loss options. You can learn more by scheduling an appointment.

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