RESULTS: We evaluated the long-term (10-year) efficacy and safety of AGA treatment with 1 mg/day finasteride in a large study population (532 patients), as the first study of this kind in Japan, to our knowledge. A high objective efficacy was demonstrated by the MGPA, which revealed improvement and prevention of disease progression in 99.1% of the 532 Japanese men with AGA treated with 1 mg/day finasteride for 10 years.
SEXUAL FUNCTION: In the investigation in 40 years or older of Asians, the incidences of decreased libido and erectile dysfunction were 6.0–38.7% and 40.6–70.0%, respectively [29,23]. Overall, the adverse reactions were all mild, and the incidence was lower than the generic incidence of decreased libido and erectile dysfunction in Asians. As adverse reactions were recorded by patients in a subjective questionnaire, the result was thought to be slightly different from the correct number of adverse reactions in this study
Dr. Rassman’s Comment: The efficacy of long term finasteride treatment has been published many times. When compared side-by-side with men who did not take finasteride, the results show that men with genetic balding hold on to more hair over time than the non-finasteride counterparts. The issue of sexual dysfunction is briefly discussed and the comment that the sexual side effects of age parallel the sexual side effects while on the drug (just slightly less according to this study). There were no cases of Past-finasteride syndrome reported in this study, a significant point.