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    62 search results for: apoptosis

    Finasteride, DHT and Apoptosis

    Apr 12, 2019/by William Rassman, M.D./0 /Hair Loss Causes
    I mean, they’re not really wrong. The only way to stop balding is to never go through puberty. Futhermore, hair loss happens with age, as we slowly slink towards the grave. Minoxidil is a growth stimulant that doesn’t address the mechanisms for why we bald, it simply provides a cosmetic effect, which is what most […]

    Very rapid hair loss at 18, why?

    Dec 8, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    Not even a chronic masturbation addiction could effect any sort of hormone levels or anything? Please help I am trying to figure out what caused me to start balding so fast at 18 Hair follicles have a biologic clock that kicks in Apoptosis (cell death) in those men who have the genes for balding. I […]

    Hair loss without miniaturization

    Oct 3, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    I’ve never heard about AGA without miniaturization and with permanent telogen. How it’s even possible, what’s the underlying mechanism? Some researchers believe that starting off the anagen cycle may be part of the AGA problem. Some men who go into telogen and catagen just don’t then pick up their anagen cycle. This will produce hair loss […]

    Effectiveness of DHT blockers

    Aug 2, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    My question is; does finasteride and dutasteride lost effectiveness over-time in the body? Like, say in decades, would my body become used to dutasteride and it will lose its effectiveness and hair loss will resume or can I preserve my hair forever (until I’m a senior, theoretically) just from taking 0.5 mg of dut everyday […]

    Long Term Class 6 pattern, what happens under the skin?

    Jun 29, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    From what I’ve read, the underlying theory for advanced classes not responding as well is due to scalp fibrosis, however that is understood to be reduced by an increase of bloodflow and microneedling. If scalp fibrosis is the culprit as to why NW6~+ don’t respond as well then hypothetically in time, enough microneedling and enough […]

    Prolactin and AGA

    Jun 2, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    Hi doctor, i have few questions (not regarding your new treatment) am just little inquisitive about hair science with regard to Prolactin and genetic hair loss and have some questions regarding that I hope you answer Prolactin Inhibition of hair growth is reported to occur via catagen induction. This is an interesting question: Neurohormone mainly […]

    My dad is bald and is 60? Can he microneedle?

    Jan 21, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    Asking on behalf of my dad. He’s 61, and I just started microneedling and telling him about it. All he has is his sides and I’ve remembered him like that for as long as I can remember (I’m 24) He seems interested in trying it and I’m letting him borrow my pen. Is there any […]

    Are juvenile hairline loss triggered by DHT?

    Jan 7, 2022/by William Rassman, M.D./0 /Hair Loss Causes
    I know what’s the difference between two cases? DHT miniaturised and non-DHT miniaturesed? What else causes miniaturisation except DHT? If the miniaturization is DHT dependent, then it occurs in the hairs of the scalp that are susceptible to DHT from genetic causes (i.e. Norwood Class 7 pattern patients). I have believed that the juvenile hairline […]

    Can fin prevent a mature hairline?

    Dec 31, 2021/by William Rassman, M.D./0 /Hair Loss Causes
    Finasteride doesn’t impact the change from a juvenile to a mature hairline because those hairs in the juvenile hairline have a limited number of cycles and are destined to die off (apoptosis). The only way to get your juvenile hairline back is to get a hair transplant to put it back.

    Mechanism of Male Pattern Balding?

    Nov 3, 2021/by William Rassman, M.D./0 /Hair Loss Causes
    Can you explain more in detail the actual mechanism of MPB? I know that some hair follicles are sensitive to DHT and somehow the DHT causes miniaturization, but how does this actually work?  Also, any wisdom on why some hairs develop later in life even where there were no (or not visible?) follicles. Like pubic […]

    Information on finasteride by Reddit poster

    Sep 8, 2021/by William Rassman, M.D./0 /Hair Loss Causes
    Dr. Rassman’s Comments:  There is some good reading here for those interested in finasteride and the many finding of things that go wrong with this drug. One of the referenced article reflect a single case study and show DNA damage to sperm.  From any single case study, one can’t conclude that the finding is attributed […]

    Extreme dieting and hair loss

    Jul 22, 2021/by William Rassman, M.D./0 /Hair Loss Causes
    I was starving myself for a year+ barely eating and it ruined my hair it’s a lot better then it was a few years ago but it never recovered fully I have seen that particularly in those men with genetic balding, starvation pushes the Apoptosis of hair follicles.

    Hair brought back with treatment

    Jun 26, 2021/by William Rassman, M.D./0 /Hair Loss Causes
    If I use the dermaroller and minoxidil without finasteride and get my hair back, will it stick around after I stop the treatment? Everything you use to keep your hair (minoxidil and dermarolling) must be continued to keep it. The same is true for finasteride. The hair that is brought back, still has its genetic […]

    Do hair follicles die in genetic balding and alopecia areata?

    Dec 31, 2020/by William Rassman, M.D./0 /Hair Loss Causes
    I know DHT shrinks hairs on male pattern baldness but Does DHT destroy the follicle? And does alopecia areata destroy the follicle or just cause hair to fall out? Hair that has genetic balding eventually die. It is called Apoptosis of the hair follicles and it is genetically coded to the number of hair cycles […]

    Wondering if bodily resistance to fin/dut is possible

    Dec 21, 2020/by William Rassman, M.D./0 /Hair Loss Causes
    Does this “tug of war” refer to the idea that your body responds to fin by increasing 5AR enzymes and therefore DHT in response to finasteride? Or does this refer to the idea that even if you inhibit 70% DHT with fin, or 90% with dut, it simply may not be enough to stop genetic […]
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